Lawrence J. Liu

This paper identifies a new class of thiophen-2-yl pyrimidines (TPPs) with improved solubility and potency against Schistosoma species, suggesting novel targets beyond tubulin.

The paper screens two small-molecule libraries for anthelmintic compounds using a C. elegans motility assay, identifying three novel compounds with varying toxicity.

This study characterizes RHBDL4 enzymatic properties using an in vitro platform, identifying effective inhibitors and providing insights for drug development.

The paper develops subunit-specific proteasome substrates for Schistosoma species, showing improved performance and cross-species applicability.