Rafael de Cabo

This study identifies CD4+ cytotoxic T cells in the bone marrow that enhance granulopoiesis in aged mice, contributing to age-related diseases and showing that CCR5 inhibition can mitigate these effects.

MSMICA improves metabolite identification in untargeted metabolomics by integrating mass spectrometry data, retention time, and biological evidence, achieving high accuracy across mammalian datasets.

Dissociated adult mouse sinoatrial node cultures stay spontaneously electrically active beyond ten days on MEA arrays and, on compliant hydrogels, permit live tracking of heterogeneous S100B-EGFP-labeled cells.

The paper identifies LANCL1-AS1 as a lncRNA that declines with age in human skeletal muscle, reduces mitochondrial activity, and impairs myogenesis by shortening mt-mRNA poly(A) tails.

SenCat catalogs senescence markers across 14 human cell types using transcriptomic and proteomic profiling, revealing shared metabolic pathways and enabling machine learning-based identification of senescent cells.

This study develops a nanoparticle-based proteomic workflow for low-volume mouse serum, identifying aging-associated proteins and demonstrating its utility in longitudinal studies.

This study shows that long-term NMN treatment improves healthspan and extends lifespan in female mice but not males, with sex-specific effects on metabolism and microbiome.

The paper identifies an aging-associated chromatin state in mice and shows that liver regeneration reverses it.

This paper develops a rat epigenetic clock (DNAmAge) that correlates with age and phenotypic aging, and identifies histone modifications linked to its signal.