Author

Mary H. Young

Bristol-Myers Squibb (United States)ORCID 0000-0003-2921-6107Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 2 Systems Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1

Frequent Co-Authors

Aye T. Chen· 2 shared Brian J. BelmontiD· 2 shared Bryce DainesiD· 2 shared Lan Shen GuoiD· 2 shared Maddie D. Williams· 2 shared Matthew R. StoneiD· 2 shared Max DarnelliD· 2 shared Nicholas BogardiD· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersImmunology

Aye T. Chen

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

ImmunologybioRxivPreprintDec 10, 2023

Switching circuits: Modulating NK cell response to TGF-β using novel receptors

Rebekah Turk, Lan Shen Guo, Brian J. Belmont…·Max Darnell

This study identifies novel switch receptors for NK cells that enhance cytotoxicity and persistence in the presence of TGF-β through a pooled screening approach.

DOI 10.1101/2023.12.10.570687

humanexperimental assay

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ImmunologybioRxivPreprintAug 2, 2023

TRAFfic signals: High-throughput CAR discovery in NK cells reveals novel TRAF-binding endodomains that drive enhanced persistence and cytotoxicity

Maddie D. Williams, Aye T. Chen, Matthew R. Stone…·Max Darnell

This study identifies TRAF-binding endodomains that enhance CAR NK cell persistence and cytotoxicity through high-throughput screening.

6 citations

humanexperimental assay

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Systems BiologyScientific ReportsPeer-reviewedFeb 5, 2020

Integrative network modeling reveals mechanisms underlying T cell exhaustion

Hamid Bolouri, Mary H. Young, Joshua N. Beilke…·Alexander V. Ratushny

The paper uses network modeling to identify molecular mechanisms driving T cell exhaustion and validates predictions through experimental testing.

27 citations

humanbulk RNA-seq

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