Author

Georgios Ioannis Karras

The University of Texas MD Anderson Cancer CenterORCID 0000-0003-2933-1535Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:drug response / drug discovery· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

Brant GraciaiD· 2 shared Patricia Montes· 2 shared Angelica M. Gutierrez‐BarreraiD· 1 shared Banu AruniD· 1 shared Junjie CheniD· 1 shared Min HuangiD· 1 shared

Activity by Year

2024-2024 · peak 2/yr

Co-Author Collaboration Network

6 top collaborators · 11 mutual co-author links

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2 shared papersGenetics

Brant GraciaORCID

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2 papers

Recent·Most cited

GeneticsbioRxivPreprintNov 15, 2024

HSP90 buffers deleterious genetic variations in BRCA1

Brant Gracia, Patricia Montes, Min Huang…·Georgios Ioannis Karras

This study shows HSP90 buffers BRCA1 mutations, reducing their clinical severity and contributing to PARP inhibitor resistance in cancer cells.

3 citations

humanprotein structure

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BiochemistryCell ReportsPeer-reviewedFeb 1, 2024

Protein-Folding Chaperones Predict Structure-Function Relationships and Cancer Risk in BRCA1 Mutation Carriers

Brant Gracia, Patricia Montes, Angelica M. Gutierrez‐Barrera…·Georgios Ioannis Karras

This study uses chaperone interactions to predict pathogenicity and cancer risk in BRCA1 mutation carriers by assessing structural and phenotypic defects.

16 citations

humanproteomics

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