Thumbi Ndung’u

The paper uses long-read sequencing to study HIV transmission and population dynamics in acute infection, finding high multilineage transmission rates and rapid viral evolution.

This study examines how the duration of initial HIV-1 viremia affects the functional properties of HIV-specific T cell receptors in individuals with HLA-B*58:01.

This study derives a scaling law for antibody language models, showing that performance improvements require both large model size and sufficient data.

This study compares neutralization profiles of contemporary HIV-1 clade C viruses from India and South Africa against broadly neutralizing antibodies, finding distinct resistance patterns and env signatures.

This study identifies CD68+ follicular macrophages in human lymph nodes as HIV reservoirs during suppressive ART, showing they harbor HIV DNA, RNA, and Gagp24 protein.

This study shows that the Sp1IIIT5A mutation in HIV-1C LTR increases transcription activity and Sp1 binding affinity, enhancing viral replication and potentially contributing to disease progression.

This study identifies oleic acid as a compound that inhibits L. iners and promotes L. crispatus growth, offering a potential new treatment strategy for bacterial vaginosis.

This study examines HIV-1 subtype C transmitted/founder virus LTR genetic variation and its impact on transcriptional activity and clinical outcomes.

The paper investigates how DNA methylation and nucleosomal occupancy regulate CXCR5 expression in human lymph node CD8+ T cells, identifying epigenetic mechanisms that repress CXCR5 in non-follicular CD8+ T cells.

The paper uses single-cell RNA-sequencing to study immune dynamics in HIV-1 infection, identifying key cellular responses and their temporal progression in untreated individuals.