Author

John W. Hanna

Brigham and Women's HospitalORCID 0000-0003-2964-1058Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1 Assay:structural biology· 1

Frequent Co-Authors

Brenda Arlene SchulmaniD· 2 shared Ellen A. GoodalliD· 2 shared Frank AdolfiD· 2 shared J. Wade HarperiD· 2 shared Susanne von Gronau· 2 shared Benedikt S. MuelleriD· 1 shared Darlene FungiD· 1 shared Ekampreet SinghiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersBiochemistry

Brenda Arlene SchulmanORCID

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintJun 4, 2026

Structural basis for regulation of the proteasome 20S core particle by the Parkinsonism-associated proteins FBXO7 and PI31

Frank Adolf, Ellen A. Goodall, Ekampreet Singh…·Brenda Arlene Schulman

This study reveals how FBXO7 and PI31 regulate the proteasome 20S core particle and how disease variants disrupt this function.

DOI 10.64898/2026.05.28.728263

humanstructural biology

𝕏 PostBluesky

BiochemistryNature Structural & Molecular BiologyPeer-reviewedApr 10, 2024

Visualizing chaperone-mediated multistep assembly of the human 20S proteasome

Frank Adolf, Jiale Du, Ellen A. Goodall…·Brenda Arlene Schulman

The paper uses cryo-EM to visualize the assembly of the human 20S proteasome, revealing how chaperones and propeptides guide subunit incorporation and proteasome activation.

32 citations

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