Julia R. Lazzari-Dean

Triplet tumbling microscopy quantifies protein complex assembly and dynamics in cells by measuring rotational diffusion of triplet states.

This paper introduces a new red-emitting fluorescent indicator, CRhOMe, capable of both monitoring and measuring membrane potentials with improved signal-to-noise and quantification using fluorescence lifetime imaging microscopy.

The paper develops a scalable platform combining microscopy and machine learning to subtype ALS patient fibroblasts, identifying a FUS-ALS phenotypic score that correlates with age and treatment response.