O. Fackler

The paper identifies a tissue-intrinsic mechanism where the extracellular matrix restricts HIV-1 infectivity and enhances innate immune detection through conformational changes in viral Env and TLR recognition.

The paper introduces FLUMMI, a peptide marker for imaging internal membranes in Plasmodium without affecting viability, and shows its compatibility with live-cell and expansion microscopy.

HIV-1 suppresses Th1 polarization by disrupting CD4 T cell-Dendritic cell communication through Nef-mediated CD4 downregulation.

This paper introduces ProDOL, a method to measure degree of labelling in cells using protein tags, and applies it to study HIV-1 Nef's effect on CD4 T cell activation.

The paper introduces ediTONSIL, a method to edit resting CD4 T cells from human tonsil tissue without activation, achieving >90% knockout efficacy and preserving cell function.

This study profiles HIV-1 integration sites in microglia and links viral insertions to topologically associated domain organization.

The paper develops an extended computational model to infer cell motility dynamics from incomplete tracking data in 3D collagen environments, showing it can reliably parameterize motility despite track loss.