Kishen M. Patel

This study identifies Vc OLD, a Class 1 OLD family nuclease from Vibrio cholerae, and its inhibitor Oad1 from phage ICP1, revealing their roles in phage defense and the bacterial-viral arms race.

The paper identifies the DarTG toxin-antitoxin system in Vibrio cholerae that inhibits the lytic phage ICP1, and shows ICP1 counters this with an antitoxin mimic, revealing co-evolutionary dynamics between the bacterium and its phage.