Pharmacology & ToxicologySciencePeer-reviewed
Targeting cancer with small molecule pan-KRAS degraders
Johannes Popow, William Farnaby, Andreas Gollner…·Alessio Ciulli
A single small molecule degrader targets 13 out of 17 prevalent oncogenic KRAS alleles, inhibiting growth of KRAS-driven cancer cell lines and inducing tumour regression in vivo.
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