Author

Aileen B. Frost

University of DundeeORCID 0009-0009-8897-0290Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

Alessio CiulliiD· 2 shared Christiane C. KofinkiD· 2 shared Claire WhitworthiD· 2 shared Emelyne DiersiD· 2 shared Harald WeinstabliD· 2 shared Manfred KoegliD· 2 shared Nicole B. TrainoriD· 2 shared Vesna VetmaiD· 2 shared

Activity by Year

2024-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersPharmacology & Toxicology

Alessio CiulliORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Pharmacology & ToxicologySciencePeer-reviewedSep 19, 2024

Targeting cancer with small molecule pan-KRAS degraders

Johannes Popow, William Farnaby, Andreas Gollner…·Alessio Ciulli

A single small molecule degrader targets 13 out of 17 prevalent oncogenic KRAS alleles, inhibiting growth of KRAS-driven cancer cell lines and inducing tumour regression in vivo.

219 citationstop 1%

humanexperimental assay

𝕏 PostBluesky

Cancer BiologyACS Chemical BiologyPeer-reviewedJul 3, 2024

Confounding factors in targeted degradation of short-lived proteins

Vesna Vetma, Laura Casares Perez, Ján Eliaš…·Manfred Koegl

This study shows that the natural half-life of a target protein significantly affects degradation by degrader agents and highlights confounding factors in screening for protein degraders.

53 citationstop 2%

statistical modeldrug response / drug discovery

𝕏 PostBluesky