Nick Powell

This paper identifies a microbiota-responsive polyfunctional cytotoxic CD4⁺ T-cell state linked to mucosal inflammation and treatment resistance in ulcerative colitis.

The paper identifies a stromal remodelling programme in ulcerative colitis patients who failed prior anti-TNF therapy, linking it to MAPK/EGFR signalling and suggesting MEK/EGFR inhibitors as potential treatments.

The paper identifies cytokine interaction networks, not individual cytokines, as the driver of anti-TNF non-response in Crohn's disease using single-cell RNA sequencing data.

This paper identifies non-coding SNPs affecting epithelial regulatory networks in UC and links them to clinical outcomes using iSNP analysis.

The paper maps cytokine interaction networks in ulcerative colitis to uncover novel pathogenic mechanisms and therapeutic targets.

This study identifies IL22-producing T-cells as regulators of epithelial-to-mesenchymal transition and extracellular matrix remodelling in perianal fistulas.

The paper identifies pQTLs for 91 plasma proteins, finds novel associations, and uses MR to uncover causal roles in immune-mediated diseases, suggesting new therapeutic targets.

The paper maps promoter interactions in human ILC3s using PCHi-C and links GWAS risk variants to target genes, identifying new autoimmune disease risk genes.

The paper introduces ExHiBITT, a colon multiomic cohort study of twins, describing its characteristics and initial findings on polyps, diverticulosis, and their associations with BMI and age.