Mitchell T. Hayes

The paper introduces multiScaleAC, a method to analyze cell-cell interactions across spatial scales using a modified Moran's I with varying kernel bandwidths, showing improved statistical power and reduced bias.

The paper identifies a transcriptional transition state in ccRCC cells that drives sarcomatoid transformation and enhances immunotherapy response via macrophage and T-cell interactions.

The paper uses spatial transcriptomics to identify increased spatial coupling of integrin and collagen IV in immunoresistant clear cell renal cell carcinoma tumors, suggesting integrin as a therapeutic target.