Cancer BiologybioRxivPreprint
A switch from histone methyltransferase-EZH2 to demethylase KDM6A activity marks reinitiation of proliferation of drug treated colorectal cancer cells
Subhashree Chatterjee, Ritika Jaiswal, Aniruddha Roy…·Rajdeep Chowdhury
This study shows that drug-treated colorectal cancer cells switch from EZH2-mediated repression to KDM6A-mediated activation, enabling reinitiation of proliferation and tumor relapse.