Ling Zhou

The paper identifies a broadly neutralizing antibody targeting the S2 subunit of sarbecoviruses, revealing a conserved site of vulnerability in the spike protein.

The paper identifies OPG153 as a target of broadly neutralizing antibodies against MPXV and related viruses using antigen-agnostic isolation, AlphaFold 3 modeling, and cryo-EM.

This paper introduces Caliby, a sequence design method that conditions on structural ensembles to improve designability while reducing native sequence recovery.

This paper describes the stabilization of HCMV gB in a prefusion-like conformation using structure-based design and shows similar neutralizing antibody titers against postfusion and prefusion forms.

This study designs stabilized SARS-CoV-2 S2 immunogens using simulation-driven approaches, showing improved stability and immunogenicity.