Patrick J. La Rivière

Chromatix provides a differentiable, GPU-accelerated wave-optics library to enable fast and parallelized optical simulations for computational optics applications.

This paper introduces a method using PBCT to create 3D virtual histology of FFPE prostate biopsies, enabling nondestructive 3D analysis of tumor architecture and distinguishing Gleason patterns.

The paper uses high-resolution microCT to create a 3D digital octopus, revealing neural pathways and organ structures from periphery to brain.

This paper introduces an algorithm to reconstruct 3D molecular orientation and density from polarized fluorescence microscopy data, demonstrating its application on biological structures and dynamics.

The paper introduces a polarized dual-view light-sheet microscope to recover 3D orientations and positions of fluorescent dipoles, validated with experiments on biological samples.

This paper introduces a deep learning method to correct optical aberrations in fluorescence microscopy, improving image quality and enabling better downstream analysis.

This paper introduces a phase diversity-based wavefront sensing method for fluorescence microscopy to correct optical aberrations efficiently and accurately.

The paper develops a semi-automated method to segment and model blood cells in zebrafish larvae using X-ray histotomography, enabling quantitative geometric analysis across developmental stages and mutants.

This paper introduces a micro-CT detector with 0.5 µm pixel size and 6 mm field-of-view, achieving 1.182 µm spatial resolution for 3D imaging of micron-scale structures in biological and non-biological samples.

The paper images a single postmortem mouse brain across five orders of spatial resolution using multiple imaging modalities to study multi-scale brain organization and pathologies.