Bastien Casu

This study identifies CisA as a membrane protein essential for the function of the Streptomyces coelicolor contractile injection system, showing it mediates recruitment to the membrane and firing.

The paper designs small molecule inhibitors of the cagT4SS ATPase Cagα in Helicobacter pylori using structure-based approaches and identifies five potent inhibitors that inhibit ATPase activity and T4SS pili assembly.