Erica A. Golemis

This study identifies ANO6-mediated trogocytosis as a mechanism by which CAFs transfer lipids to PDAC cells, promoting tumor growth and immune suppression.

The paper identifies a germline KDM3C polymorphism linked to impaired DNA repair and increased sensitivity to chemoradiotherapy in cancers like rectal and head and neck squamous cell carcinomas.

The paper shows that SMN inactivation causes CB components to invade the nucleolus, suppressing rRNA production and telomerase function through altered condensate interactions.

The paper identifies small molecules that stabilize and restore function to missense-mutated VHL proteins in kidney cancer cells.

This study shows that AURKA inhibition increases DNA replication stress in TP53-mutated cancers, creating a dependency on WEE1 that can be exploited with combined AURKA and WEE1 inhibition to enhance antitumor effects.

The paper identifies DNA repair and replication defects in early-onset renal cancer patients without known germline variants, suggesting these defects contribute to cancer development and may inform treatment strategies.

The paper classifies over 700 RAS structures into conformations based on SW1 and SW2 loops, identifies mutation impacts, and creates a database for analysis.

The paper examines the prevalence of pathogenic variants in DNA damage response genes in early-onset renal cancer patients undergoing genetic testing and finds that DDR gene variants are present in 8.55% of patients.