Amit Das

This study investigates how IQGAP1 disrupts the β-catenin/α-catenin complex through mechanical detachment and electrostatic interactions using simulations and mutagenesis.

The paper develops a physical model of cell-cell junctions to study hybrid E/M states during EMT, revealing mechanochemical landscapes and identifying differences in mechanosensitivity between cadherin isoforms.

The paper shows that actin flows sort membrane proteins based on their affinity for actin, leading to specific clustering and patterning.

The paper investigates how steric hindrance and stratification affect actomyosin organization, showing that simulations and microscopy reveal stratified patterns in vitro that differ from in vivo observations.