Author

Roeland J.W. Middelbeek

Joslin Diabetes CenterORCID 0000-0003-3862-8082Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:differential expression· 2 Approach:statistical model· 2 Approach:benchmark study· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Laurie J. GoodyeariD· 2 shared Maria T. VamviniiD· 2 shared Michael F. HirshmaniD· 2 shared Pasquale NigroiD· 2 shared Benjamin T. JamesiD· 1 shared Danae Papadopoulos· 1 shared Hui Zhang· 1 shared Jeu ParkiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

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10 top collaborators · 40 mutual co-author links

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2 shared papersMolecular Biology

Laurie J. GoodyearORCID

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2 papers

Recent·Most cited

Molecular BiologybioRxivPreprintOct 11, 2025

Type 2 Diabetes and Obesity Alter Exercise Training-Induced Transcriptional Adaptations to Subcutaneous White Adipose Tissue

Roeland J.W. Middelbeek, Jiekun Yang, Pasquale Nigro…·Laurie J. Goodyear

This study examines how exercise training affects subcutaneous white adipose tissue transcriptomes in individuals with obesity and T2D, finding that exercise reverses detrimental gene expression patterns and correlates with improved metabolic markers.

DOI 10.1101/2025.10.11.681273

humanbulk RNA-seq

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PhysiologyCell ReportsPeer-reviewedJul 1, 2024

Exercise Training and Cold Exposure Trigger Distinct Molecular Adaptations to Inguinal White Adipose Tissue

Maria T. Vamvini, Pasquale Nigro, Tiziana Caputo…·Laurie J. Goodyear

This study compares molecular adaptations in inguinal white adipose tissue from exercise-trained and cold-exposed mice, showing distinct proteomic and secretomic changes that affect systemic glucose metabolism.

13 citations

mouseproteomics

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