Jan Šilhán

This study determines the structure of the hibernating F. tularensis ribosome and shows RaiA and antibiotics bound to it, offering insights for therapeutic intervention.

This study clarifies the mechanism of NEIL3 in unhooking Ap-ICLs by showing that a processed form of NEIL3 efficiently removes crosslinks without generating strand breaks.

This study identifies the role of the SLX4-XPF-ERCC1 nuclease complex in repairing alcohol-induced DNA crosslinks by making two precise incisions around the lesion.

The paper presents the cryo-EM structure of the human 20S proteasome bound to marizomib, revealing its binding mode and irreversible inhibitory mechanism.

This study determines the cryo-EM structures of recombinant Trichomonas vaginalis 20S proteasome bound to covalent inhibitors, revealing their binding modes and explaining inhibitor specificity.

The paper solves the crystal structure of the SARS-CoV-2 nsp10-nsp16 MTase complex and models its interaction with RNA, revealing low conservation with Zika MTase and implications for inhibitor design.