Maxime Barrault

This study identifies IsrR as a small RNA that downregulates MiaB, an iron-sulfur cluster-containing tRNA methylthiotransferase, under iron-deficient conditions in S. aureus.

The paper shows that IsrR, an sRNA, controls aconitase expression in S. aureus during iron deficiency through a feedforward loop and aconitase's moonlighting activity regulates central metabolism.