Eric A. Singer

This paper identifies a chromatin-altered subtype of urothelial carcinoma defined by SWI/SNF alterations, showing it is sensitive to HDAC inhibition and immunotherapy.

This paper identifies biologically distinct transcriptomic and proteomic patterns of ADC and immunotherapy targets in urothelial carcinoma, linking them to histologic and molecular subtypes for precision therapy.

This study examines epigenetic, microbiome, and immune differences in early-onset colorectal cancer (EOCRC) compared to average-onset CRC, finding accelerated epigenetic aging and stronger immune-microbe correlations in EOCRC.

The paper examines how hypoxia affects the tumor microbiome and its interaction with radiation response in colorectal cancer using RNA-seq data and experimental models.

The paper introduces MEGA, a tool to identify cancer-associated microbes using RNA-seq data from the ORIEN dataset, leveraging graph attention networks and microbial community information.