Christopher J. Hatch

This paper develops a microphysiological HHT-on-a-chip platform that recapitulates patient vascular lesions and demonstrates sensitivity to pazopanib, a drug effective in HHT patients.

The paper presents an image processing pipeline for analyzing vascularized micro-organ and tumor systems using Fiji/ImageJ tools, reducing manual processing time and enabling real-time imaging insights.

The paper uses a vascularized micro-tumor model to identify therapeutic targets in TNBC stromal interactions, showing efficacy of Tie2 and Her3/Akt inhibition.