Cédric Belair

This study identifies cell-type-specific RNA isoform changes in aging mouse brain using single-cell and long-read sequencing, revealing altered coding potential and senescence markers in immune cells.

This study shows that DNA hydroxymethylation in gene bodies limits transcriptional changes with age in mouse and human tissues.

The paper introduces RNAkinet, a deep learning model that uses nanopore sequencing to analyze RNA dynamics and cis-regulatory elements at single molecule resolution.

This study uses direct RNA sequencing to show that cellular stress causes widespread 5' end RNA decay linked to stress granules, independent of deadenylation or decapping.

The paper shows that loss of TDP-43 function leads to the expression of de novo proteins from mis-spliced mRNA transcripts in ALS/FTD.

The paper investigates how senescence affects the integrated stress response and secretory phenotype in human cells, finding that translational repression of ATF4 reduces stress response and enhances inflammation.