Alexandros C. Kokotos

This study identifies NDK as a key gene at the intersection of guanosine nucleotide metabolism and bioenergetics, showing its protective role in Parkinson's disease and its association with genetic risk.

This paper identifies SLC13A5 as a genetic driver of epileptic encephalopathy that regulates presynaptic glycolysis by clearing axonal citrate during electrical activity.

The paper identifies PGK1 as a rate-limiting enzyme in axonal metabolism and shows its protective role against Parkinson's disease-related synaptic deficits.

The paper develops iATPSnFR2, a high dynamic range fluorescent ATP sensor for real-time subcellular ATP monitoring, showing improved performance over previous versions.