Author

Adrian Moises Molina Vargas

University of Rochester MedicineORCID 0000-0003-4090-1180Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Assay:CRISPR screen· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Amun C. PateliD· 2 shared Giulia PalermoiD· 2 shared Mitchell R. O’ConnelliD· 2 shared Pablo R Arantes· 2 shared Souvik SinhaiD· 2 shared Andrew CameroniD· 1 shared Dwight J. Hardy· 1 shared Raven M. OsborniD· 1 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

9 top collaborators · 36 mutual co-author links

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2 shared papersMolecular Biology

Amun C. PatelORCID

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2 papers

Recent·Most cited

Molecular BiologyNucleic Acids ResearchPeer-reviewedNov 9, 2023

New design strategies for ultra-specific CRISPR-Cas13a-based RNA-diagnostic tools with single-nucleotide mismatch sensitivity

Adrian Moises Molina Vargas, Souvik Sinha, Raven M. Osborn…·Mitchell R. O’Connell

This paper develops new CRISPR-Cas13a variants and crRNA design strategies to improve RNA-detection specificity, achieving better discrimination of SARS-CoV-2 strains.

110 citationstop 1%

CRISPR screenexperimental assay

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BiophysicsNucleic Acids ResearchPeer-reviewedNov 9, 2023

RNA-mediated Allosteric Activation in CRISPR-Cas13a

Souvik Sinha, Adrian Moises Molina Vargas, Pablo R Arantes…·Giulia Palermo

This study elucidates the allosteric activation mechanism of CRISPR-Cas13a using molecular dynamics simulations and experiments, revealing key residues critical for RNA cleavage selectivity.

44 citations

proteomicsdeep learning

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