Ulises Hernández

The paper estimates human genetic load variation due to rare and ultra-rare deleterious mutations, showing significant ancestral fitness differences between individuals.

The paper compares the effects of mutational drought and meltdown on extinction risk in small populations, finding mutational drought is more significant in stable and changing environments.

The paper shows that high human deleterious mutation rates slow adaptation and increase fitness variance, but also suggest that increased mutation rates can speed adaptation.