Cancer BiologyScience AdvancesPeer-reviewed
IRF8-mutant B cell lymphoma evades immunity through a CD74-dependent deregulation of antigen processing and presentation in MHC CII complexes
Zhijun Qiu, Jihane Khalife, Purushoth Ethiraj…·Ricardo C.T. Aguiar
This study shows that IRF8 mutations in DLBCL lymphomas impair antigen processing and presentation by reducing CD74 and HLA-DM, leading to immune evasion and increased tumor burden.
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