Jonas Fischer

The paper benchmarks DNA methylation sequencing workflows against an experimental gold-standard, identifying superior workflows and developing a sustainable benchmarking platform.

The paper identifies sex differences in lung adenocarcinoma by integrating multi-omics data to discover sex-biased signaling pathways and potential sex-specific therapies.

This study investigates how loss of the Y chromosome in lung adenocarcinoma affects the tumor immune environment and response to immunotherapy.

The paper identifies sex differences in gene regulatory networks in lung adenocarcinoma and identifies potential sex-biased cancer therapeutics.

PHOENIX uses biologically informed neural ODEs to infer genome-wide regulatory dynamics, demonstrating scalability and interpretability in simulated and real data.

The paper integrates single cell RNA-seq with bulk epigenomic data to identify distinct regulatory states in bidirectional promoters and their associations with structural features and TF binding.