Samantha M. Barnada

The paper identifies lung cancer-specific p53 mutants that bind genomic sites but fail to activate transcription, revealing a novel loss-of-function mechanism in lung cancer.

This study shows SALL4 recruits BAF to CNCC-specific enhancers for neural crest induction, and SALL4A is essential for this process.

This study examines how PARP inhibitors affect transcriptional responses in prostate cancer patients of different racial backgrounds, finding race-based differences in PARP1 expression and distinct transcriptional programs for each inhibitor.

This study identifies non-redundant roles for DCP1a and DCP1b in mRNA decapping, showing distinct functions in complex assembly and translational machinery interactions.

The paper shows ARID1A-haploinsufficiency impairs EMT in CNCC specification by disrupting ARID1A-BAF binding at EMT enhancers, which affects ZIC2 occupancy and leads to aberrant neuronal gene activation.

This study identifies JUN upregulation as a driver of transposable element mobilization, innate immune activation, and impaired neurogenesis in Alzheimer's disease.

The paper identifies species-specific transposon-derived enhancers contributing to transcriptomic differences in human and chimpanzee hippocampal intermediate progenitors.

The paper identifies genomic features that enable SVA transposons to function as cis-regulatory elements in human pluripotent stem cells, showing their impact on gene expression.