Morten Grønbech Rasch

This paper introduces Proton-PottsMPNN, a model that designs pH-sensitive binders by explicitly modeling protonation states, resulting in pH-dependent PD-L1 binders with transition pH values between 4.0 and 5.8.

The paper maps Gcg-expressing neuron populations in mice, identifies fasting-responsive GLP-1 neurons in the posterior hypothalamic nucleus, and shows their projections and functional regulation.

This study evaluates Gremlin-1 as a therapeutic target in MASH fibrosis, finding it upregulated but not amenable to targeting due to its restricted expression and lack of effect on fibrogenesis.