Megan A. Outram

This study uses AlphaFold2 to analyze the structural diversity of effector proteins in rust fungi secretomes, identifying structurally related clusters and metal-binding effector candidates.

The paper investigates the structural role of zinc coordination in the wheat rust effector AvrSr33, showing it provides a scaffold necessary for immune recognition by Sr33.

The paper determines cryo-EM structures of a plant TNL NLR, revealing its activation mechanism and NAD+ recognition, which informs engineering disease-resistant crops.

The paper identifies AvrPm4, a mildew effector recognised by the wheat resistance gene Pm4, and shows that virulent isolates evade resistance via SvrPm4, which suppresses AvrPm4-induced cell death.

This study examines the evolution and function of NIP2 paralogs in Rhynchosporium commune, showing their genomic distribution, expression during infection, and potential virulence roles.

The paper identifies a two-component resistance mechanism in wheat where a tandem kinase sensor recruits an NLR helper to trigger immunity against fungal pathogens.

The paper identifies that CsoSCA, a carboxysomal carbonic anhydrase in cyanobacteria, is allosterically activated by RuBP, revealing a regulatory mechanism in CO2 fixation.

The paper reports the crystal structure of AvrSr27, a Pgt effector, revealing its modular zinc-bound fold and its role in immune recognition by Sr27.

This study identifies Rph7, a barley resistance gene against leaf rust, as a putative NAC transcription factor involved in basal defence activation.