Rajan Sankaranarayanan

This study identifies a Dip2-mediated Pkc1 signalling axis regulated by specific DAGs that maintains mitochondrial integrity in yeast.

The paper identifies bacterial homologues of the mitochondrial ATP/ADP carrier, resolving its evolutionary origin as a bacterial ancestor.

The paper identifies Dip2 as a conserved regulator of DAG-based PKC signaling in eukaryotes, showing its role in maintaining specific DAG subpopulations required for PKC-mediated pathways.

This study shows that the archaeal DTD2 enzyme protects plants from aldehyde toxicity by removing harmful adducts on tRNA, and its overexpression enhances aldehyde resistance in Arabidopsis.