Cancer BiologybioRxivPreprint
CBL mutations in pediatric solid and CNS tumors are a marker of receptor tyrosine kinase activation and a potential therapeutic target
Lauren M. Brown, Chelsea Mayoh, Katherine A Camper…·Paul G. Ekert
1 citation
Author
University of LeicesterORCID 0000-0003-4530-0798Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
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Lauren M. Brown, Chelsea Mayoh, Katherine A Camper…·Paul G. Ekert
MoonSun Jung, Valentina Poltavets, Joanna N. Skhinas…·Maria Kavallaris
This paper develops patient-derived tumour models using engineered ECM hydrogels to enable precision medicine for paediatric cancers by retaining tumour genotype and phenotype.
Charlie J. Hitchman, Andrea Lia, Mohammed Bhogadia…·Pietro Roversi
The paper determines Cryo-EM structures of the EDEM:PDI complex with and without a substrate, revealing how disulfide bonds regulate conformational changes essential for substrate engagement.