Author

Michelle K. Knowles

University of DenverORCID 0000-0003-4538-9104Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Assay:imaging· 2 Approach:microscopy & imaging analysis· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Approach:experimental assay· 1

Frequent Co-Authors

Broderick L. BillsiD· 2 shared Megan L. Hulser· 2 shared André Allen· 1 shared Melodie T. Nguyen· 1 shared Sisiyan Jiang· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

5 top collaborators · 10 mutual co-author links

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2 shared papersBiophysics

Broderick L. BillsORCID

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2 papers

Recent·Most cited

BiophysicsBiophysical JournalPeer-reviewedApr 6, 2026

Phospholipase D1 and Phosphatidic Acid are required for MVE Fusion and Exosome Secretion

Melodie T. Nguyen, Broderick L. Bills, André Allen…·Michelle K. Knowles

This study shows that phospholipase D1 (PLD1) and phosphatidic acid (PA) regulate MVE fusion and exosome release by promoting docking-to-fusion transition and correlating with exosome release rate.

DOI 10.1016/j.bpj.2026.04.002

humanimaging

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Cell BiologyMolecular Biology of the CellPeer-reviewedDec 20, 2023

Phospholipase D1 Produces Phosphatidic Acid at Sites of Secretory Vesicle Docking and Fusion

Broderick L. Bills, Megan L. Hulser, Michelle K. Knowles

This study shows PLD1 produces phosphatidic acid (PA) at secretory vesicle docking and fusion sites, with PA levels decreasing during fusion when PLD1 is inhibited.

7 citations

humanimaging

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