The mechanical response of vinculin
Xuyao Liu, Jingzhun Liu, Yinan Wang…·Jie Yan
This study examines vinculin's mechanical properties, finding it unfolds and refolds in response to force, suggesting it acts as a mechanotransducer.
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National University of SingaporeORCID 0000-0003-4585-8310Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
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Xuyao Liu, Jingzhun Liu, Yinan Wang…·Jie Yan
This study examines vinculin's mechanical properties, finding it unfolds and refolds in response to force, suggesting it acts as a mechanotransducer.
This paper develops a model to predict the tension-dependent lifetime of Tension Gauge Tethers (TGTs) and validates it with experimental data.
Wenmao Huang, Jingzhun Liu, Shimin Le…·Jie Yan
This study uses in-situ single-molecule techniques to identify a partially folded conformation of α-synuclein and shows its sensitivity to biochemical perturbations and drugs.