Cancer BiologyMolecular OncologyPeer-reviewed
MET variants with activating N-lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation
Célia Guérin, Audrey Vinchent, Marie Fernandes…·David Tulasne
This paper identifies N-lobe MET mutations in HPRCC that require ligand stimulation for activation, unlike kinase domain mutations, and shows their sensitivity to MET inhibitors.
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