Author

Nicholas Michelarakis

Heidelberg Institute for Theoretical StudiesORCID 0000-0003-4618-2850Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 1

Signature Assays, Organisms & Methods

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Organism:human· 1 Approach:mechanistic / dynamical model· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

Camilo A. Aponte-SantamariaiD· 1 shared Frauke GräteriD· 1 shared Rita Ann RoessneriD· 1 shared

Activity by Year

2023-2023 · peak 1/yr

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3 top collaborators · 3 mutual co-author links

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1 shared paperBiophysics

Camilo A. Aponte-SantamariaORCID

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1 paper

Recent·Most cited

BiophysicsPLoS Computational BiologyPeer-reviewedDec 20, 2023

Mechanical forces control the valency of the malaria adhesin VAR2CSA by exposing cryptic glycan binding sites

Rita Ann Roessner, Nicholas Michelarakis, Frauke Gräter, Camilo A. Aponte-Santamaria

This study shows mechanical forces increase VAR2CSA's binding avidity by converting it from monovalent to multivalent through conformational changes exposing additional CSA binding sites.

2 citations

humanprotein structure

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