Sergey Malitsky

This study identifies a bacterial defense system, Metis, that detects virus-induced genome degradation through methylated mononucleotides, leading to inhibition of phage infection.

The paper identifies a bacterial defense mechanism, aRES, that depletes NAD+ by producing ADPR-1P, which resists phage NARP1 reconstitution, and describes phage countermeasures including phosphatases and inhibitors.

The paper shows that algal betaine triggers bacterial hydrogen peroxide production, leading to algal death in marine interactions.

This study identifies intracellular carbon storage via PHB granules as a key mechanism for starvation survival in marine bacteria, with additional strategies also contributing to persistence.

This study shows that p53 inactivation promotes breast cancer brain metastasis by altering fatty acid metabolism, with implications for therapeutic targeting.

The paper develops hMultiCLEM, a high-resolution screening pipeline combining EM and multiplexed human cell pools to identify proteins affecting mitochondrial cristae shape, uncovering MISHA linked to Meniere's disease.

This study examines how the production of tropodithietic acid (TDA) affects microbial physiology and interactions across varying culture complexities, showing gene deletion impacts co-cultures but not tri-cultures with algal hosts.

The paper develops a pipeline to identify condition-specific enzymes in yeast, revealing a function for the uncharacterized Bdh2 alcohol dehydrogenase.

This study identifies a bacterial immune system where TIR-domain proteins activate caspase-like proteases to induce cell death and block phage replication.

This study shows that MTCH2 deletion increases energy demand and metabolic imbalance in cells, which inhibits adipocyte differentiation.

This study shows that osmotic stress in roots leads to lipoxygenase-dependent plastid remodeling and singlet oxygen production, which affects root growth and cell survival.

This study identifies two phage pathways, NARP1 and NARP2, that reconstitute NAD+ from its degradation products to counter bacterial immunity.

This study identifies Yet3 as a protein that recruits sterol biosynthesis enzymes to ER contact sites, enabling on-demand sterol production and influencing organellar structure and function.

This study shows Emiliania huxleyi produces vitamin D2 and D3 in response to UV radiation and regulates protective mechanisms transcriptionally when exposed to vitamin D, enhancing photosynthesis and reducing oxidative stress.

The paper uses a bi-genomic split-GFP assay to identify mitochondrial matrix and inner membrane proteins, revealing 50 previously unvisualized proteins and characterizing dually localized proteins.

This study shows that obesity accelerates cognitive decline in Alzheimer's mice via sialic acid-driven immune changes.

The paper shows that BCKDK compensates for PDK family loss by inactivating PDC, maintaining TCA cycle function and embryonic development in mice.