César A. Ramírez‐Sarmiento

This paper redesigns PET hydrolase PHL7 using MPNN models to enhance its catalytic activity at lower temperatures, achieving efficiency comparable to its activity at higher temperatures.

The paper predicts RfaH homolog structures using AlphaFold2, identifies active-state homologs, and supports a stepwise evolutionary model of RfaH specialization.

This study identifies diverse polyester-degrading enzymes in polar marine microbes, revealing their potential for cold-adapted plastic bioremediation.

FrustraMPNN rapidly predicts single-residue frustration in proteins at proteome scale with high accuracy, enabling new insights into protein function and dynamics.

The paper investigates SCP2's interaction with PFAS, showing it binds PFAS for the first time and identifies residues involved in this interaction.

This paper describes open educational resources for teaching molecular biology techniques using locally produced reagents, open-source hardware, and free software, demonstrating their effectiveness in remote and low-resource settings.

This paper reveals how RfaH activates virulence gene expression by transforming its structure and stabilizing paused transcription complexes through interactions with ops hairpins.

The paper analyzes local energetic frustration in protein families to uncover stability and function constraints, demonstrating its application to SARS-CoV-2 and poorly characterized proteins.