Joseph E. Chambers

The paper identifies three GCN2 activators, one of which works independently of GCN1, and describes its unique binding mechanism.

This paper develops DNA-peptide nanostructures to multivalently inhibit TNKS, showing they effectively downregulate Wnt signaling in cancer cells despite differences in TBP copy number.

This paper introduces a method combining single-molecule light-field microscopy with widefield Fourier light-field microscopy to improve volumetric subcellular imaging and molecular diffusion analysis.

The paper shows that ER morphology affects neuronal bursting by controlling Ca2+ refill rates, linking ER structure to neuronal activity and neurodegeneration.

The paper identifies convergent somatic escape variants in SERPINA1 in A1AT deficiency patients, showing adaptive mutations that counteract the disease-causing germline variant.

This study develops a medium-throughput assay to assess leptin secretion and identifies mutations causing proteasomal degradation or reduced secretion.