Jonathan Dorogin

This paper designs BMP-2 binders using AI pipelines to control bone regeneration, finding a binder with 2.07 nM affinity for BMP-2.

This paper develops IL-4-specific affibodies to control cytokine delivery and bioactivity, showing reduced IL-4 release and partial signaling inhibition in macrophages.

This paper develops a hydrogel system that combines mechanical reinforcement with affinity-controlled BMP-2 release to improve bone regeneration in rat models.

This paper engineers affibodies with tunable affinities for VEGF and PDGF using computational design and yeast display to improve controlled protein release from hydrogels.

This study compares synthetic and recombinant BMP-2-specific affibodies, finding they have similar structure and function but synthetic ones have lower endotoxin levels and higher yield.

The paper optimizes hydrazone-crosslinked hyaluronic acid hydrogels for protein delivery using design of experiments, identifying an optimal formulation that meets specific physicochemical and functional criteria.