Jens Peter von Kries

This paper expands the known ligand space of Cereblon by identifying new chemically distinct ligands that bind through non-canonical mechanisms.

The paper presents a morphological profiling dataset of EU-OPENSCREEN bioactive compounds across multiple imaging sites and cell lines, validated for robustness and used to map profiles to activity and toxicity.

This study presents the first structural description of the fusobacterial TAA CbpF and its interaction with CEACAM1, revealing a novel binding mode and potential targets for drug design in CRC.

The paper identifies a drug-like molecule that inhibits EHD4's liposome-stimulated ATPase activity and provides SAR insights for improved inhibitor design.

This study identifies 7,8-dihydroxyflavone as a direct inhibitor of pyridoxal phosphatase, increasing PLP levels in mouse hippocampal neurons and validating PDXP as a druggable target.

This study identifies TSG101 as essential for PARylation and DNA damage-induced NF-κB activation, showing its role in DNA repair and apoptosis protection.