Peng Zheng

This paper designs ultrastable helical proteins using AI and chemistry, achieving high mechanical, thermal, and chemical stability.

The paper identifies a conserved heparan sulfate binding domain in MPXV H3 using AI and MD simulations, validates its role in viral adhesion, and demonstrates a protein inhibitor that disrupts this interaction, inhibiting infection in vitro and in vivo.

This paper introduces a method for site-specific conjugation of proteins to PNA using a strict protein ligase, enabling erasable imaging of membrane proteins.