Danilo Horta

CellRegMap identifies context-specific regulatory variants using scRNA-seq by analyzing allelic effects across cell types and states.

The paper maps regulatory effects of human disease variants in pluripotent cells, identifying cis- and trans-QTL across 18,556 genes and linking them to GWAS traits.

This paper introduces StructLMM, a linear mixed model for analyzing multivariate gene-environment interactions, demonstrating its effectiveness in detecting GxE signals in BMI and eQTL data.

The paper introduces iSet, a method for detecting gene-context interactions using linear mixed models, and finds it identifies more interactions than alternative methods, including a gene-sex interaction for C-reactive protein.