Author
Tri-Institutional PhD Program in Chemical BiologyORCID 0000-0003-4880-2195Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
Recent·Most cited
Hiroyuki Kojima, Charlotte R. Wayne, Luis F. Somarribas Patterson…·Ekaterina V. Vinogradova
In chronically stimulated human T cells, suppressed oxidative metabolism and nucleotide loss accompany MAP2K4 activation. Inhibiting MAP2K4 (with the MKK4/7 inhibitor BSJ-04-122) restored tumor-cell killing in vitro.
Tiffany Zhang, Henry Sanford, Railia R Gabbasova…·Ekaterina V. Vinogradova
The paper uses multi-omics approaches to study post-translational changes in macrophages during activation, identifying endosomal mRNA transport as a target of inflammation.
Kevin A. Scott, Hiroyuki Kojima, Nathalie Ropek…·Ekaterina V. Vinogradova
This study develops chemical probes to target splicing factors in T cells, showing state-dependent loss of ITK via SF3B1 and demonstrating covalent ligandability of splicing regulators.