Charles David Imbusch

This study shows that HSC dormancy, not apoptosis, limits mutagenesis in aging, with dormancy disruption accelerating mutation rates.

This study identifies epigenetic changes in AT2 cells from COPD patients that disrupt IFN and WNT pathways, impairing lung regeneration.

The paper introduces CFS, a method to compare cell groups across datasets without integration, identifying conserved astrocyte subpopulations in mouse motor cortex and spinal cord.

This paper develops a computational framework to quantify telomere content and composition from scATAC-seq data, revealing patient-specific telomere maintenance patterns in cancer and immune cells.

The paper integrates single cell RNA-seq with bulk epigenomic data to identify distinct regulatory states in bidirectional promoters and their associations with structural features and TF binding.