Michio Hiroshima

This study uses single-molecule tracking to screen FDA-approved drugs for effects on EGFR mobility and clustering, identifying both known and novel compounds that impact EGFR function.

This study uses super-resolution microscopy to show that EGFR and PI(4,5)P2 nanodomains coaggregate before EGF stimulation, and their interaction is regulated by phospholipase Cγ and PI(4,5)P2 levels.

The paper investigates how differences in ERBB receptor expression and phosphorylation rates contribute to diverse phosphorylation dynamics across organs.

The paper analyzes single-cell responses to growth factors using phosphorylation data to show cell-to-cell variation in signal transduction and suggests a bet-hedging strategy in fate decisions.