Linus A. Hein

This paper identifies high-performance split sites in DNA aptamers through large-scale mutational analysis, improving signal-to-background ratio for RNA detection.

This paper introduces a method to sequence peptides by converting them into DNA barcodes and demonstrates its ability to detect single amino acid substitutions and post-translational modifications.

This paper develops high-specificity DNA aptamers for progesterone using a high-throughput array platform, achieving nanomolar affinity and minimal cross-reactivity with structurally similar steroids.

This paper presents a mathematical framework and experimental validation to enable accurate multiplexed analyte quantification using cross-reactive affinity reagents.

This paper introduces MAPA, a high-throughput platform for discovering and optimizing aptamer beacons for molecular targets, demonstrating its effectiveness for glucose, serotonin, and dopamine.

The paper develops a hydrogel-based sensor to measure extracellular signaling molecules in real-time and demonstrates its use for cAMP in Dictyostelium discoideum.